• Confocal imaging of paraffin-embedded Human tonsil tissue using CD35/CR1 Rabbit monoclonal antibody (STJ11101917, dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) ( dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.
  • Immunohistochemistry analysis of CD35/CR1 in paraffin-embedded human tonsil using CD35/CR1 Rabbit monoclonal antibody (STJ11101917) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-CR1 antibody (1940-2039) [S7MR] (STJ11101917)

SKU:
STJ11101917

£146.50 - £639.50
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Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CD35 (1940-2039) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S7MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CR1
Gene ID: 1378
Uniprot ID: CR1_HUMAN
Immunogen Region: 1940-2039
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1940-2039 of human CD35/CR1 (P17927).
Immunogen Sequence: DGYTLEGSPWSQCQADDRWD PPLAKCTSRTHDALIVGTLS GTIFFILLIIFLSWIILKHR KGNNAHENPKEVAIHLHSQG GSSVHPRTLQTNEENSRVLP
Tissue Specificity Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.
Function Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Protein Name Complement Receptor Type 1
C3b/C4b Receptor
Cd Antigen Cd35
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8877330
Reactome: R-HSA-977606
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Complement Receptor Type 1 antibody
Anti-C3b/C4b Receptor antibody
Anti-Cd Antigen Cd35 antibody
Anti-CR1 antibody
Anti-C3BR antibody

Information sourced from Uniprot.org

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