| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INTS11 |
| Gene ID: | 54973 |
| Uniprot ID: | INT11_HUMAN |
| Immunogen Region: | 331-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 331-600 of human CPSF3L (NP_060341.2). |
| Immunogen Sequence: | GQSLQIFRKWAGNEKNMVIM PGYCVQGTVGHKILSGQRKL EMEGRQVLEVKMQVEYMSFS AHADAKGIMQLVGQAEPESV LLVHGEAKKMEFLKQKIEQE LRVNCYMPANGETVTLPTSP SIPVGISLGLLKREMAQGLL PEAKKPRLLHGTLIMKDSNF RLVSSEQALKELGLAEHQLR FTCRVHLHDTRKEQETALRV YSHLKSVLKDHCVQHLPDGS VTVESVLLQAAAPSEDPGT |
| Function | Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. |
| Protein Name | Integrator Complex Subunit 11Int11Cleavage And Polyadenylation-Specific Factor 3-Like ProteinCpsf3-Like ProteinProtein Related To Cpsf Subunits Of 68 KdaRc-68 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 11 antibodyAnti-Int11 antibodyAnti-Cleavage And Polyadenylation-Specific Factor 3-Like Protein antibodyAnti-Cpsf3-Like Protein antibodyAnti-Protein Related To Cpsf Subunits Of 68 Kda antibodyAnti-Rc-68 antibodyAnti-INTS11 antibodyAnti-CPSF3L antibodyAnti-RC68 antibody |
Information sourced from Uniprot.org