| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Carbamoyl-phosphate synthase, mitochondrial (816-866) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CPS1 |
| Gene ID: | 1373 |
| Uniprot ID: | CPSM_HUMAN |
| Immunogen Region: | 816-866 |
| Specificity: | This antibody detects endogenous levels of human CPSM |
| Immunogen: | Synthesized peptide derived from human CPSM AA range: 816-866 |
| Post Translational Modifications | Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. |
| Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Protein Name | Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial Carbamoyl-Phosphate Synthetase I Cpsase I |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | Mitochondrion Nucleus Nucleolus Cell Membrane Peripheral Membrane Protein Extracellular Side Localizes To The Cell Surface Of Hepatocytes |
| Alternative Antibody Names | Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibody Anti-Carbamoyl-Phosphate Synthetase I antibody Anti-Cpsase I antibody Anti-CPS1 antibody |
Information sourced from Uniprot.org