| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Carbamoyl-phosphate synthase, mitochondrial (816-866) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPS1 |
| Gene ID: |
1373 |
| Uniprot ID: |
CPSM_HUMAN |
| Immunogen Region: |
816-866 |
| Specificity: |
This antibody detects endogenous levels of human CPSM |
| Immunogen: |
Synthesized peptide derived from human CPSM AA range: 816-866 |
| Post Translational Modifications | Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. |
| Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Protein Name | Carbamoyl-Phosphate Synthase Ammonia - MitochondrialCarbamoyl-Phosphate Synthetase ICpsase I |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | MitochondrionNucleusNucleolusCell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Cell Surface Of Hepatocytes |
| Alternative Antibody Names | Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibodyAnti-Carbamoyl-Phosphate Synthetase I antibodyAnti-Cpsase I antibodyAnti-CPS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
