Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CPS1 |
Gene ID: | 1373 |
Uniprot ID: | CPSM_HUMAN |
Immunogen Region: | 750-970 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-970 of human CPS1 (NP_001866.2). |
Immunogen Sequence: | IKNVVSGKTSACFEPSLDYM VTKIPRWDLDRFHGTSSRIG SSMKSVGEVMAIGRTFEESF QKALRMCHPSIEGFTPRLPM NKEWPSNLDLRKELSEPSST RIYAIAKAIDDNMSLDEIEK LTYIDKWFLYKMRDILNMEK TLKGLNSESMTEETLKRAKE IGFSDKQISKCLGLTEAQTR ELRLKKNIHPWVKQIDTLAA EYPSVTNYLYVTYNGQEHDV N |
Tissue Specificity | Primarily in the liver and small intestine. |
Post Translational Modifications | Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. |
Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
Protein Name | Carbamoyl-Phosphate Synthase Ammonia - MitochondrialCarbamoyl-Phosphate Synthetase ICpsase I |
Database Links | Reactome: R-HSA-70635 |
Cellular Localisation | MitochondrionNucleusNucleolusCell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Cell Surface Of Hepatocytes |
Alternative Antibody Names | Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibodyAnti-Carbamoyl-Phosphate Synthetase I antibodyAnti-Cpsase I antibodyAnti-CPS1 antibody |
Information sourced from Uniprot.org