| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis. |
| Protein Name | CeruloplasminCuproxidase CeruloplasminFerroxidase CeruloplasminGlutathione Peroxidase CeruloplasminGlutathione-Dependent Peroxiredoxin Ceruloplasmin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-8957275Reactome: R-HSA-917937 |
| Cellular Localisation | SecretedColocalizes With Gcp1 In Secretory Intracellular Compartments |
| Alternative Antibody Names | Anti-Ceruloplasmin antibodyAnti-Cuproxidase Ceruloplasmin antibodyAnti-Ferroxidase Ceruloplasmin antibodyAnti-Glutathione Peroxidase Ceruloplasmin antibodyAnti-Glutathione-Dependent Peroxiredoxin Ceruloplasmin antibodyAnti-CP antibody |
Information sourced from Uniprot.org
