• STJ70408 (0. 5µg/ml) staining of Daudi (A) , MOLT4 (B) and (1ug/ml) of Jurkat (C) cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ70408 (0. 5µg/ml) staining of Human Lymph node (A) and Spleen (B) lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ70408 Flow cytometric analysis of paraformaldehyde fixed Jurkat cells (blue line) , permeabilized with 0. 5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Anti-Coronin 1/TACO antibody (C-Term) (STJ70408)

SKU:
STJ70408-100

£303.50
Shipping:
Free Shipping
Current Stock:
Host: Goat
Applications: Pep-ELISA/WB/IHC/FC
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Coronin 1/TACO (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Flow Cytometry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
FC-Flow cytometric analysis of Jurkat cells. 10ug/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CORO1A
Gene ID: 11151
Uniprot ID: COR1A_HUMAN
Immunogen Region: C-Term
Accession Number: NP_009005.1
Immunogen Sequence: KRLDRLEETVQAK
Post Translational Modifications phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.
Function May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Protein Name Coronin-1a
Coronin-Like Protein A
Clipin-A
Coronin-Like Protein P57
Tryptophan Aspartate-Containing Coat Protein
Taco
Database Links Reactome: R-HSA-9636383
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Cortex
Cytoplasmic Vesicle
Phagosome Membrane
In Non-Infected Macrophages
Associated With The Cortical Microtubule Network
In Mycobacteria-Infected Macrophages
Becomes Progressively Relocalized And Retained Around The Mycobacterial Phagosomes
Retention On The Phagosomal Membrane Is Strictly Dependent On Mycobacterial Viability And Not Due To Impaired Acidification
Alternative Antibody Names Anti-Coronin-1a antibody
Anti-Coronin-Like Protein A antibody
Anti-Clipin-A antibody
Anti-Coronin-Like Protein P57 antibody
Anti-Tryptophan Aspartate-Containing Coat Protein antibody
Anti-Taco antibody
Anti-CORO1A antibody
Anti-CORO1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance