| Post Translational Modifications | Phosphorylated by CK2 and PKD kinases. |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
| Protein Name | Cop9 Signalosome Complex Subunit 2Sgn2Signalosome Subunit 2Alien HomologJab1-Containing Signalosome Subunit 2Thyroid Receptor-Interacting Protein 15Tr-Interacting Protein 15Trip-15 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 2 antibodyAnti-Sgn2 antibodyAnti-Signalosome Subunit 2 antibodyAnti-Alien Homolog antibodyAnti-Jab1-Containing Signalosome Subunit 2 antibodyAnti-Thyroid Receptor-Interacting Protein 15 antibodyAnti-Tr-Interacting Protein 15 antibodyAnti-Trip-15 antibodyAnti-COPS2 antibodyAnti-CSN2 antibodyAnti-TRIP15 antibody |
Information sourced from Uniprot.org
