| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COLEC12 (60-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COLEC12 |
| Gene ID: |
81035 |
| Uniprot ID: |
COL12_HUMAN |
| Immunogen Region: |
60-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human COLEC12 (NP_569057.1). |
| Immunogen Sequence: |
KVVEKMDNVTGGMETSRQTY DDKLTAVESDLKKLGDQTGK KAISTNSELSTFRSDILDLR QQLREITEKTSKNKDTLEKL QASGDALVDRQSQLKETLEN NSFLITTVNKTLQAYNGYVT NLQQDTSVLQGNLQNQMYSH NVVIMNLNNLNLTQVQQRNL ITNLQRSVDDTSQAIQRIKN DFQNLQQVFLQAKKDTDWLK EKVQSLQTLAA |
| Tissue Specificity | Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. |
| Function | Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. |
| Protein Name | Collectin-12Collectin Placenta Protein 1Cl-P1Hcl-P1Nurse Cell Scavenger Receptor 2Scavenger Receptor Class A Member 4Scavenger Receptor With C-Type Lectin |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-3000480 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinForms Clusters On The Cell Surface |
| Alternative Antibody Names | Anti-Collectin-12 antibodyAnti-Collectin Placenta Protein 1 antibodyAnti-Cl-P1 antibodyAnti-Hcl-P1 antibodyAnti-Nurse Cell Scavenger Receptor 2 antibodyAnti-Scavenger Receptor Class A Member 4 antibodyAnti-Scavenger Receptor With C-Type Lectin antibodyAnti-COLEC12 antibodyAnti-CLP1 antibodyAnti-NSR2 antibodyAnti-SCARA4 antibodyAnti-SRCL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
