| Tissue Specificity | Ubiquitous. Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level). |
| Function | Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. |
| Protein Name | Collectin-11Collectin Kidney Protein 1Cl-K1 |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-3000480 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Collectin-11 antibodyAnti-Collectin Kidney Protein 1 antibodyAnti-Cl-K1 antibodyAnti-COLEC11 antibodyAnti-UNQ596 antibodyAnti-PRO1182 antibody |
Information sourced from Uniprot.org
