| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Coilin is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COIL |
| Gene ID: | 8161 |
| Uniprot ID: | COIL_HUMAN |
| Specificity: | This antibody detects endogenous levels of Coilin at Human |
| Immunogen: | Synthesized peptide derived from human Coilin |
| Post Translational Modifications | Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs. Phosphorylated by VRK1. Phosphorylation during mitosis is associated with disassembly of CBs. |
| Function | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. |
| Protein Name | CoilinP80-Coilin |
| Cellular Localisation | NucleusCajal Body |
| Alternative Antibody Names | Anti-Coilin antibodyAnti-P80-Coilin antibodyAnti-COIL antibodyAnti-CLN80 antibody |
Information sourced from Uniprot.org