| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNTN6 |
| Gene ID: | 27255 |
| Uniprot ID: | CNTN6_HUMAN |
| Immunogen Region: | 20-110 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human CNTN6 (NP_055276.1). |
| Immunogen Sequence: | DGLLSRPIFTQEPHDVIFPL DLSKSEVILNCAANGYPSPH YRWKQNGTDIDFTMSYHYRL DGGSLAINSPHTDQDIGMYQ CLATNLLGTIL |
| Tissue Specificity | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. |
| Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. |
| Protein Name | Contactin-6Neural Recognition Molecule Nb-3Hnb-3 |
| Database Links | Reactome: R-HSA-447041 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Contactin-6 antibodyAnti-Neural Recognition Molecule Nb-3 antibodyAnti-Hnb-3 antibodyAnti-CNTN6 antibody |
Information sourced from Uniprot.org