Anti-CNTN1 antibody (250-350) (STJ119575)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CNTN1 (250-350) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNTN1 |
| Gene ID | 1272 |
| Uniprot ID | CNTN1_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | LECFALGNPVPDIRWRKVLE PMPSTAEISTSGAVLKIFNI QLEDEGIYECEAENIRGKDK HQARIYVQAFPEWVEHINDT EVDIGSDLYWPCVATGKPIP T |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CNTN1 (NP_778203.1). |
Additional Info
| Tissue Specificity | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
| Protein Name | Contactin-1Glycoprotein Gp135Neural Cell Surface Protein F3 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2979096Reactome: R-HSA-373760Reactome: R-HSA-447043 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Contactin-1 antibodyAnti-Glycoprotein Gp135 antibodyAnti-Neural Cell Surface Protein F3 antibodyAnti-CNTN1 antibody |
Information sourced from Uniprot.org