| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:400-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNTFR |
| Gene ID: | 1271 |
| Uniprot ID: | CNTFR_HUMAN |
| Immunogen Region: | 90-342 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1). |
| Immunogen Sequence: | FHRDSWHLRHQVLLHVGLPP REPVLSCRSNTYPKGFYCSW HLPTPTYIPNTFNVTVLHGS KIMVCEKDPALKNRCHIRYM HLFSTIKYKVSISVSNALGH NATAITFDEFTIVKPDPPEN VVARPVPSNPRRLEVTWQTP STWPDPESFPLKFFLRYRPL ILDQWQHVELSDGTAHTITD AYAGKEYIIQVAAKDNEIGT WSDWSVAAHATPWTEEPRHL TTEAQAAETTTSTTSSLAP |
| Tissue Specificity | Nervous system and skeletal muscle. |
| Function | Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1. |
| Protein Name | Ciliary Neurotrophic Factor Receptor Subunit AlphaCntf Receptor Subunit AlphaCntfr-Alpha |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Ciliary Neurotrophic Factor Receptor Subunit Alpha antibodyAnti-Cntf Receptor Subunit Alpha antibodyAnti-Cntfr-Alpha antibodyAnti-CNTFR antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and PAK4 knockout (KO) 293T cells, using [KO Validated] PAK4 Rabbit pAb (STJ11100032) at 1:500 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 3min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89104/405569/STJ11100032_1__78296.1744891338.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PAK4 knockout (KO) 293T cells, using [KO Validated] PAK4 Rabbit pAb (STJ11100032) at 1:500 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 3min.")
