| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNTD1 |
| Gene ID: | 124817 |
| Uniprot ID: | CNTD1_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CNTD1 (NP_001317151.1). |
| Immunogen Sequence: | MVKQAENICRQATIQPRDNK RESQNWRALKQQLVNKFTLR LVSCVQLASKLSFRNKIISN ITVLNFLQALGYLHTKEELL ESELDVLKSLNFRINLPTPL AYVETLLEVLGYNGCLVPAM |
| Function | Plays a role in the different steps of crossover formation during meiotic recombination. Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19. In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1. May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates. |
| Protein Name | Cyclin N-Terminal Domain-Containing Protein 1 |
| Cellular Localisation | NucleusCytoplasmChromosomeShuttles Between The Nucleus And Cytoplasm In A Stage-Specific Manner Of Prophase I CellsCo-Localized At Crossover Sites With Prr19 |
| Alternative Antibody Names | Anti-Cyclin N-Terminal Domain-Containing Protein 1 antibodyAnti-CNTD1 antibodyAnti-CNTD antibody |
Information sourced from Uniprot.org
