| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CNR2 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNR2 |
| Gene ID: |
1269 |
| Uniprot ID: |
CNR2_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CNR2 (NP_001832.1). |
| Immunogen Sequence: |
MEECWVTEIANGSKDGLDSN PMKDYMILSGPQKTAVAVLC TLLGLLSALENVAVLYLILS SHQLRRKPSYLFIGSLAGAD FLASVVFACSFVNFHVFHGV |
| Tissue Specificity | Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. |
| Post Translational Modifications | Constitutively phosphorylated on Ser-352.phosphorylation increases cell internalization and desensitizes the receptor. |
| Function | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. |
| Protein Name | Cannabinoid Receptor 2Cb-2Cb2Hcb2Cx5 |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendritePerikaryonLocalizes To Apical Dendrite Of Pyramidal Neurons |
| Alternative Antibody Names | Anti-Cannabinoid Receptor 2 antibodyAnti-Cb-2 antibodyAnti-Cb2 antibodyAnti-Hcb2 antibodyAnti-Cx5 antibodyAnti-CNR2 antibodyAnti-CB2A antibodyAnti-CB2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
