| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CCR4-NOT transcription complex subunit 4 (61-110 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNOT4 |
| Gene ID: | 4850 |
| Uniprot ID: | CNOT4_HUMAN |
| Immunogen Region: | 61-110 aa |
| Specificity: | CNOT4 Polyclonal Antibody detects endogenous levels of CNOT4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CNOT4 at the amino acid range 61-110 |
| Function | Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 4Ccr4-Associated Factor 4E3 Ubiquitin-Protein Ligase Cnot4Potential Transcriptional Repressor Not4hpRing-Type E3 Ubiquitin Transferase Cnot4 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 4 antibodyAnti-Ccr4-Associated Factor 4 antibodyAnti-E3 Ubiquitin-Protein Ligase Cnot4 antibodyAnti-Potential Transcriptional Repressor Not4hp antibodyAnti-Ring-Type E3 Ubiquitin Transferase Cnot4 antibodyAnti-CNOT4 antibodyAnti-NOT4 antibody |
Information sourced from Uniprot.org