| Tissue Specificity | Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. |
| Function | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 1Ccr4-Associated Factor 1Negative Regulator Of Transcription Subunit 1 HomologNot1hHnot1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmP-BodyNucleusNanos2 Promotes Its Localization To P-Body |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 1 antibodyAnti-Ccr4-Associated Factor 1 antibodyAnti-Negative Regulator Of Transcription Subunit 1 Homolog antibodyAnti-Not1h antibodyAnti-Hnot1 antibodyAnti-CNOT1 antibodyAnti-CDC39 antibodyAnti-KIAA1007 antibodyAnti-NOT1 antibodyAnti-AD-005 antibody |
Information sourced from Uniprot.org
