| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNOT1 |
| Gene ID: |
23019 |
| Uniprot ID: |
CNOT1_HUMAN |
| Immunogen Region: |
2137-2376 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3). |
| Immunogen Sequence: |
PRNMRLPDPFTPNLKVDMLS EINIAPRILTNFTGVMPPQF KKDLDSYLKTRSPVTFLSDL RSNLQVSNEPGNRYNLQLIN ALVLYVGTQAIAHIHNKGST PSMSTITHSAHMDIFQNLAV DLDTEGRYLFLNAIANQLRY PNSHTHYFSCTMLYLFAEAN TEAIQEQITRVLLERLIVNR PHPWGLLITFIELIKNPAFK FWNHEFVHCAPEIEKLFQSV AQCCMGQKQAQQVMEGTGA |
| Tissue Specificity | Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. |
| Function | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 1Ccr4-Associated Factor 1Negative Regulator Of Transcription Subunit 1 HomologNot1hHnot1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmP-BodyNucleusNanos2 Promotes Its Localization To P-Body |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 1 antibodyAnti-Ccr4-Associated Factor 1 antibodyAnti-Negative Regulator Of Transcription Subunit 1 Homolog antibodyAnti-Not1h antibodyAnti-Hnot1 antibodyAnti-CNOT1 antibodyAnti-CDC39 antibodyAnti-KIAA1007 antibodyAnti-NOT1 antibodyAnti-AD-005 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
