| Tissue Specificity | Isoform 1: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes. Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level). Isoform 2: Broadly expressed in fetal tissues. Expressed in adult liver and placenta. |
| Function | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis. |
| Protein Name | Cytosolic Non-Specific DipeptidaseCndp Dipeptidase 2Glutamate Carboxypeptidase-Like Protein 1Peptidase AThreonyl Dipeptidase |
| Database Links | Reactome: R-HSA-174403Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Cytosolic Non-Specific Dipeptidase antibodyAnti-Cndp Dipeptidase 2 antibodyAnti-Glutamate Carboxypeptidase-Like Protein 1 antibodyAnti-Peptidase A antibodyAnti-Threonyl Dipeptidase antibodyAnti-CNDP2 antibodyAnti-CN2 antibodyAnti-CPGL antibodyAnti-HEL-S-13 antibodyAnti-PEPA antibody |
Information sourced from Uniprot.org
