| Tissue Specificity | Expressed in the leukocytes, placenta and testis. |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 6Chemokine-Like Factor Superfamily Member 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCo-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibodyAnti-Chemokine-Like Factor Superfamily Member 6 antibodyAnti-CMTM6 antibodyAnti-CKLFSF6 antibody |
Information sourced from Uniprot.org
