| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4263RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:20000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMTM6 |
| Gene ID: | 54918 |
| Uniprot ID: | CKLF6_HUMAN |
| Immunogen Region: | 84-183 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 84-183 of human CMTM6 (NP_060271.1). |
| Immunogen Sequence: | LILIVYCTPFYERVDTTKVK SSDFYITLGTGCVFLLASII FVSTHDRTSAEIAAIVFGFI ASFMFLLDFITMLYEKRQES QLRKPENTTRAEALTEPLNA |
| Tissue Specificity | Expressed in the leukocytes, placenta and testis. |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 Chemokine-Like Factor Superfamily Member 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Early Endosome Membrane Recycling Endosome Membrane Co-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibody Anti-Chemokine-Like Factor Superfamily Member 6 antibody Anti-CMTM6 antibody Anti-CKLFSF6 antibody |
Information sourced from Uniprot.org
