| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLTA |
| Gene ID: | 1211 |
| Uniprot ID: | CLCA_HUMAN |
| Immunogen Region: | 1-218 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human CLTA (NP_001824.1). |
| Immunogen Sequence: | MAELDPFGAPAGAPGGPALG NGVAGAGEEDPAAAFLAQQE SEIAGIENDEAFAILDGGAP GPQPHGEPPGGPDAVDGVMN GEYYQESNGPTDSYAAISQV DRLQSEPESIRKWREEQMER LEALDANSRKQEAEWKEKAI KELEEWYARQDEQLQKTKAN NRAAEEAFVNDIDESSPGTE WERVARLCDFNPKSSKQAKD VSRMRSVLISLKQAPLVH |
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. |
| Protein Name | Clathrin Light Chain A Lca |
| Database Links | Reactome: R-HSA-168275 Reactome: R-HSA-177504 Reactome: R-HSA-190873 Reactome: R-HSA-196025 Reactome: R-HSA-2132295 Reactome: R-HSA-3928665 Reactome: R-HSA-432720 Reactome: R-HSA-432722 P09496-1 Reactome: R-HSA-437239 Reactome: R-HSA-5099900 Reactome: R-HSA-5140745 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8866427 Reactome: R-HSA-8964038 |
| Cellular Localisation | Cytoplasmic Vesicle Membrane Peripheral Membrane Protein Cytoplasmic Side Membrane Coated Pit Cytoplasm Cytoskeleton Spindle Cytoplasmic Face Of Coated Pits And Vesicles In Complex With Tacc3 And Ckap5 (Forming The Tacc3/Ch-Tog/Clathrin Complex) Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Clathrin Light Chain A antibody Anti-Lca antibody Anti-CLTA antibody |
Information sourced from Uniprot.org