| Tissue Specificity | Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes. |
| Post Translational Modifications | Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. |
| Function | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. |
| Protein Name | Mitochondrial DisaggregaseSuppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form |
| Database Links | |
| Cellular Localisation | Mitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Mitochondrial Disaggregase antibodyAnti-Suppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form antibodyAnti-CLPB antibodyAnti-SKD3 antibody |
Information sourced from Uniprot.org
