Anti-CLEC5A/MDL1 antibody [DX246] (STJA0027053)

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STJA0027053-100
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Short Description :Human monoclonal C-Type Lectin Domain Family 5 Member A antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC
Host:Human
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :DX246
Isotype:IgG1k
Conjugation:Unconjugated
Concentration:2.17 mg/ml
Purification:Protein A/G purified from cell culture supernatant.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:CLEC5A
Gene ID:23601
Uniprot ID:CLC5A_HUMAN
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release.
Protein Name C-Type Lectin Domain Family 5 Member A
C-Type Lectin Superfamily Member 5
Myeloid Dap12-Associating Lectin 1
Mdl-1
Database Links Reactome: R-HSA-2172127
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-C-Type Lectin Domain Family 5 Member A antibody
Anti-C-Type Lectin Superfamily Member 5 antibody
Anti-Myeloid Dap12-Associating Lectin 1 antibody
Anti-Mdl-1 antibody
Anti-CLEC5A antibody
Anti-CLECSF5 antibody
Anti-MDL1 antibody

Information sourced from Uniprot.org

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