| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC4C (45-213) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC4C |
| Gene ID: |
170482 |
| Uniprot ID: |
CLC4C_HUMAN |
| Immunogen Region: |
45-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1). |
| Immunogen Sequence: |
NFMYSKTVKRLSKLREYQQY HPSLTCVMEGKDIEDWSCCP TPWTSFQSSCYFISTGMQSW TKSQKNCSVMGADLVVINTR EEQDFIIQNLKRNSSYFLGL SDPGGRRHWQWVDQTPYNEN VTFWHSGEPNNLDERCAIIN FRSSEEWGWNDIHCHVPQKS ICKMKKIYI |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. |
| Function | Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. |
| Protein Name | C-Type Lectin Domain Family 4 Member CBlood Dendritic Cell Antigen 2Bdca-2C-Type Lectin Superfamily Member 7Dendritic LectinCd Antigen Cd303 |
| Database Links | Reactome: R-HSA-5621480Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member C antibodyAnti-Blood Dendritic Cell Antigen 2 antibodyAnti-Bdca-2 antibodyAnti-C-Type Lectin Superfamily Member 7 antibodyAnti-Dendritic Lectin antibodyAnti-Cd Antigen Cd303 antibodyAnti-CLEC4C antibodyAnti-BDCA2 antibodyAnti-CLECSF11 antibodyAnti-CLECSF7 antibodyAnti-DLEC antibodyAnti-HECL antibodyAnti-UNQ9361 antibodyAnti-PRO34150 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
