Western blot analysis of lysates from K-562 cells, using CLEC4C Rabbit pAb (STJ115657) at 1:3000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 10s.

Anti-CLEC4C antibody (45-213) (STJ115657)

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STJ115657
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Applications:WB/ELISA
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:CLEC4C
Gene ID:170482
Uniprot ID:CLC4C_HUMAN
Immunogen Region:45-213
Immunogen Sequence:NFMYSKTVKRLSKLREYQQY HPSLTCVMEGKDIEDWSCCP TPWTSFQSSCYFISTGMQSW TKSQKNCSVMGADLVVINTR EEQDFIIQNLKRNSSYFLGL SDPGGRRHWQWVDQTPYNEN VTFWHSGEPNNLDERCAIIN FRSSEEWGWNDIHCHVPQKS ICKMKKIYI
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1).
Tissue Specificity Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
Function Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
Protein Name C-Type Lectin Domain Family 4 Member C
Blood Dendritic Cell Antigen 2
Bdca-2
C-Type Lectin Superfamily Member 7
Dendritic Lectin
Cd Antigen Cd303
Database Links Reactome: R-HSA-5621480
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member C antibody
Anti-Blood Dendritic Cell Antigen 2 antibody
Anti-Bdca-2 antibody
Anti-C-Type Lectin Superfamily Member 7 antibody
Anti-Dendritic Lectin antibody
Anti-Cd Antigen Cd303 antibody
Anti-CLEC4C antibody
Anti-BDCA2 antibody
Anti-CLECSF11 antibody
Anti-CLECSF7 antibody
Anti-DLEC antibody
Anti-HECL antibody
Anti-UNQ9361 antibody
Anti-PRO34150 antibody

Information sourced from Uniprot.org

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