| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC2B |
| Gene ID: |
9976 |
| Uniprot ID: |
CLC2B_HUMAN |
| Immunogen Region: |
40-120 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human CLEC2B (NP_005118.2). |
| Immunogen Sequence: |
IGFQNKCYYFSKEEGDWNSS KYNCSTQHADLTIIDNIEEM NFLRRYKCSSDHWIGLKMAK NRTGQWVDGATFTKSFGMRG S |
| Tissue Specificity | Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types. |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. N-linked glycosylated.required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites. |
| Function | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. |
| Protein Name | C-Type Lectin Domain Family 2 Member BActivation-Induced C-Type LectinC-Type Lectin Superfamily Member 2Ifn-Alpha-2b-Inducing-Related Protein 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneResting Nk Cells Contain Intracellular Stores Of Clec2b Associated With The Golgi Complex |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 2 Member B antibodyAnti-Activation-Induced C-Type Lectin antibodyAnti-C-Type Lectin Superfamily Member 2 antibodyAnti-Ifn-Alpha-2b-Inducing-Related Protein 1 antibodyAnti-CLEC2B antibodyAnti-AICL antibodyAnti-CLECSF2 antibodyAnti-IFNRG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
