| Short Description : | Goat polyclonal antibody anti-CLEC16A (1040-53) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | Pep-ELISA/WB |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx. 110kDa band observed in Human Kidney and Liver lysates (calculated MW of 118kDa according to NP_056041.1). Recommended concentration: 1-3µg/ml. |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CLEC16A |
| Gene ID: | 23274 |
| Uniprot ID: | CL16A_HUMAN |
| Accession Number: | NP_056041.1 |
| Immunogen Region: | 1040-53 |
| Immunogen Sequence: | EEAACAEPVGTAED |
| Function | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. |
| Protein Name | Protein Clec16aC-Type Lectin Domain Family 16 Member A |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembraneAssociates With The Endolysosome Membrane |
| Alternative Antibody Names | Anti-Protein Clec16a antibodyAnti-C-Type Lectin Domain Family 16 Member A antibodyAnti-CLEC16A antibodyAnti-KIAA0350 antibody |
Information sourced from Uniprot.org
