• Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-MMP20-Tyr108 antibody (107-108) (STJA0005891)

SKU:
STJA0005891

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Matrix metalloproteinase-20-Tyr108 (107-108) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMP20
Gene ID: 9313
Uniprot ID: MMP20_HUMAN
Immunogen Region: 107-108
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat MMP20 (Cleaved-Tyr108, protein was cleaved amino acid sequence between 107-108 )
Immunogen: Synthesized peptide derived from human MMP20 (Cleaved-Tyr108)
Tissue Specificity Expressed specifically in the enamel organ.
Post Translational Modifications Autoactivates at least at the 107-Asn-|-Tyr-108 site.
Function Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
Protein Name Matrix Metalloproteinase-20
Mmp-20
Enamel Metalloproteinase
Enamelysin
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-2022090
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Matrix Metalloproteinase-20 antibody
Anti-Mmp-20 antibody
Anti-Enamel Metalloproteinase antibody
Anti-Enamelysin antibody
Anti-MMP20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance