| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cleaved-Matrix metalloproteinase-20-Tyr108 (107-108) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MMP20 |
| Gene ID: | 9313 |
| Uniprot ID: | MMP20_HUMAN |
| Immunogen Region: | 107-108 |
| Specificity: | This antibody detects endogenous levels of Human, Mouse, Rat MMP20 (Cleaved-Tyr108, protein was cleaved amino acid sequence between 107-108 ) |
| Immunogen: | Synthesized peptide derived from human MMP20 (Cleaved-Tyr108) |
| Tissue Specificity | Expressed specifically in the enamel organ. |
| Post Translational Modifications | Autoactivates at least at the 107-Asn-|-Tyr-108 site. |
| Function | Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. |
| Protein Name | Matrix Metalloproteinase-20 Mmp-20 Enamel Metalloproteinase Enamelysin |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-2022090 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-20 antibody Anti-Mmp-20 antibody Anti-Enamel Metalloproteinase antibody Anti-Enamelysin antibody Anti-MMP20 antibody |
Information sourced from Uniprot.org