• Immunohistochemical analysis of paraffin-embedded human meningioma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-KLK7-Ile30 antibody (29-30) (STJA0005886)

SKU:
STJA0005886

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Kallikrein-7-Ile30 (29-30) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLK7
Gene ID: 5650
Uniprot ID: KLK7_HUMAN
Immunogen Region: 29-30
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat Kallikrein-7 (Cleaved-Ile30, protein was cleaved amino acid sequence between 29-30 )
Immunogen: Synthesized peptide derived from human Kallikrein-7 (Cleaved-Ile30)
Tissue Specificity Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Protein Name Kallikrein-7
Hk7
Serine Protease 6
Stratum Corneum Chymotryptic Enzyme
Hscce
Database Links Reactome: R-HSA-1474228
Cellular Localisation Secreted
In Ovarian Carcinoma
Secreted And Also Observed At The Apical Membrane And In Cytoplasm At The Invasive Front
Alternative Antibody Names Anti-Kallikrein-7 antibody
Anti-Hk7 antibody
Anti-Serine Protease 6 antibody
Anti-Stratum Corneum Chymotryptic Enzyme antibody
Anti-Hscce antibody
Anti-KLK7 antibody
Anti-PRSS6 antibody
Anti-SCCE antibody

Information sourced from Uniprot.org

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