| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cleaved-Caspase-10-Val220 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA-Pep 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASP10 |
| Gene ID: | 843 |
| Uniprot ID: | CASPA_HUMAN |
| Specificity: | This antibody detects endogenous levels of human Caspase 10 (p23/17, Cleaved-Val220) |
| Immunogen: | Synthesized peptide derived from the human Caspase 10 (p23/17, Cleaved-Val220) |
| Post Translational Modifications | Cleavage by granzyme B and autocatalytic activity generate the two active subunits. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. |
| Protein Name | Caspase-10 Casp-10 Apoptotic Protease Mch-4 Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 Flice2 Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 |
| Database Links | Reactome: R-HSA-6803207 Reactome: R-HSA-75157 Reactome: R-HSA-75158 Reactome: R-HSA-933543 |
| Alternative Antibody Names | Anti-Caspase-10 antibody Anti-Casp-10 antibody Anti-Apoptotic Protease Mch-4 antibody Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody Anti-Flice2 antibody Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody Anti-CASP10 antibody Anti-MCH4 antibody |
Information sourced from Uniprot.org