• Western blot analysis of lysates from Jurkat cells, treated with Etoposide 25uM 60', using Aggrecan (Cleaved-Asp369) Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Aggrecan (Cleaved-Asp369) Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-Cleaved-ACAN-D369 antibody (320-369 aa) (STJ90041)

SKU:
STJ90041

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Aggrecan core protein-D369 (320-369 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACAN
Gene ID: 176
Uniprot ID: PGCA_HUMAN
Immunogen Region: 320-369 aa
Specificity: Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Aggrecan at the amino acid range 320-369
Post Translational Modifications Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
Function This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Protein Name Aggrecan Core Protein
Cartilage-Specific Proteoglycan Core Protein
Cspcp
Chondroitin Sulfate Proteoglycan Core Protein 1
Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-2022854
Reactome: R-HSA-2022857
Reactome: R-HSA-3000178
Reactome: R-HSA-3656225
Reactome: R-HSA-3656243
Reactome: R-HSA-3656244
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Aggrecan Core Protein antibody
Anti-Cartilage-Specific Proteoglycan Core Protein antibody
Anti-Cspcp antibody
Anti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibody
Anti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibody
Anti-ACAN antibody
Anti-AGC1 antibody
Anti-CSPG1 antibody
Anti-MSK16 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance