| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5280RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:3000-1:12000IHC-P:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLDN6 |
| Gene ID: | 9074 |
| Uniprot ID: | CLD6_HUMAN |
| Immunogen Region: | 119-219 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 119-219 of human Claudin 6 (NP_067018.2) |
| Immunogen Sequence: | SGIVFVISGVLTLIPVCWTA HAIIRDFYNPLVAEAQKREL GASLYLGWAASGLLLLGGGL LCCTCPSGGSQGPSHYMARY STSAPAISRGPSEYPTKNYV |
| Tissue Specificity | Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. |
| Protein Name | Claudin-6Skullin |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-6 antibodyAnti-Skullin antibodyAnti-CLDN6 antibodyAnti-UNQ757 antibodyAnti-PRO1488 antibody |
Information sourced from Uniprot.org