| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLDN10 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN10 |
| Gene ID: |
9071 |
| Uniprot ID: |
CLD10_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN10 (NP_008915.1). |
| Immunogen Sequence: |
MASTASEIIAFMVSISGWVL VSSTLPTDYWKVSTIDGTVI TTATYWANLWKACVTDSTGV SNCKDFPSMLALDGYIQACR GLMIAAVSLGFFGSIFALFG |
| Tissue Specificity | Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores.isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. |
| Protein Name | Claudin-10Oligodendrocyte-Specific Protein-LikeOsp-Like |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-10 antibodyAnti-Oligodendrocyte-Specific Protein-Like antibodyAnti-Osp-Like antibodyAnti-CLDN10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
