| Tissue Specificity | Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells. |
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. Isoform 1: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. Isoform 2: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. |
| Protein Name | Claudin-10Oligodendrocyte-Specific Protein-LikeOsp-Like |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Isoform 1: Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinIsoform 2: Cell Junction |
| Alternative Antibody Names | Anti-Claudin-10 antibodyAnti-Oligodendrocyte-Specific Protein-Like antibodyAnti-Osp-Like antibodyAnti-CLDN10 antibody |
Information sourced from Uniprot.org
