| Tissue Specificity | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. |
| Post Translational Modifications | Ubiquitinated by NEDD4L in the presence of albumin.which promotes endocytosis and proteasomal degradation. |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
| Protein Name | H(+/Cl(- Exchange Transporter 5Chloride Channel Protein 5Clc-5Chloride Transporter Clc-5 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 5 antibodyAnti-Chloride Channel Protein 5 antibodyAnti-Clc-5 antibodyAnti-Chloride Transporter Clc-5 antibodyAnti-CLCN5 antibodyAnti-CLCK2 antibody |
Information sourced from Uniprot.org
