| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Calcium-activated chloride channel regulator 2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLCA2 |
| Gene ID: | 9635 |
| Uniprot ID: | CLCA2_HUMAN |
| Specificity: | This antibody detects endogenous levels of CLCA2 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human CLCA2 |
| Post Translational Modifications | The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated. |
| Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 2 Calcium-Activated Chloride Channel Family Member 2 Hclca2 Calcium-Activated Chloride Channel Protein 3 Cacc-3 Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Basal Cell Membrane Cell Junction Calcium-Activated Chloride Channel Regulator 2 109 Kda Form: Secreted Remains Associated To The 35 Kda Form Until An Unidentified Event Triggers The Release |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 2 antibody Anti-Calcium-Activated Chloride Channel Family Member 2 antibody Anti-Hclca2 antibody Anti-Calcium-Activated Chloride Channel Protein 3 antibody Anti-Cacc-3 antibody Anti-Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form antibody Anti-CLCA2 antibody Anti-CACC3 antibody |
Information sourced from Uniprot.org