Anti-CLCA2 antibody (STJA0007664)

SKU:
STJA0007664
£49.00 - £261.00
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Short Description :Rabbit polyclonal anti-Calcium-activated chloride channel regulator 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range:WB 1:500-2000
Formulation:Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:CLCA2
Gene ID:9635
Uniprot ID:CLCA2_HUMAN
Immunogen:Synthesized peptide derived from human CLCA2
Specificity:This antibody detects endogenous levels of CLCA2 at Human, Mouse
Post Translational Modifications The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated.
Function Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
Protein Name Calcium-Activated Chloride Channel Regulator 2
Calcium-Activated Chloride Channel Family Member 2
Hclca2
Calcium-Activated Chloride Channel Protein 3
Cacc-3
Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form
Database Links Reactome: R-HSA-2672351
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Basal Cell Membrane
Cell Junction
Calcium-Activated Chloride Channel Regulator 2
109 Kda Form: Secreted
Remains Associated To The 35 Kda Form Until An Unidentified Event Triggers The Release
Alternative Antibody Names Anti-Calcium-Activated Chloride Channel Regulator 2 antibody
Anti-Calcium-Activated Chloride Channel Family Member 2 antibody
Anti-Hclca2 antibody
Anti-Calcium-Activated Chloride Channel Protein 3 antibody
Anti-Cacc-3 antibody
Anti-Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form antibody
Anti-CLCA2 antibody
Anti-CACC3 antibody

Information sourced from Uniprot.org

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