| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CLCA2 |
| Gene ID: |
9635 |
| Uniprot ID: |
CLCA2_HUMAN |
| Immunogen Region: |
32-160 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 32-160 of human CLCA2 (NP_006527.1). |
| Immunogen Sequence: |
GVQLQDNGYNGLLIAINPQV PENQNLISNIKEMITEASFY LFNATKRRVFFRNIKILIPA TWKANNNSKIKQESYEKANV IVTDWYGAHGDDPYTLQYRG CGKEGKYIHFTPNFLLNDNL TAGYGSRGR |
| Tissue Specificity | Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. |
| Post Translational Modifications | The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated. |
| Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 2Calcium-Activated Chloride Channel Family Member 2Hclca2Calcium-Activated Chloride Channel Protein 3Cacc-3Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasal Cell MembraneCell JunctionCalcium-Activated Chloride Channel Regulator 2109 Kda Form: SecretedRemains Associated To The 35 Kda Form Until An Unidentified Event Triggers The Release |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 2 antibodyAnti-Calcium-Activated Chloride Channel Family Member 2 antibodyAnti-Hclca2 antibodyAnti-Calcium-Activated Chloride Channel Protein 3 antibodyAnti-Cacc-3 antibodyAnti-Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form antibodyAnti-CLCA2 antibodyAnti-CACC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
