Anti-Claudin 8 antibody (STJA0037886)

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STJA0037886
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Short Description :Rabbit monoclonal anti-Claudin 8 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity Purified
Dilution Range:IHC 1:100-1:200
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:CLDN8
Gene ID:9073
Uniprot ID:CLD8_HUMAN
Immunogen:A synthesized peptide derived from human Claudin 8
Tissue Specificity Expressed in the epididymis, mainly in the caput segment.
Post Translational Modifications Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.
Function Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own.
Protein Name Claudin-8
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Localizes To Tight Junctions In All 3 Segments Of The Epididymis
In The Caput Found In The Lateral Margins Of Principal Cells
And In The Corpus At The Interface Between Basal And Principal Cells
Alternative Antibody Names Anti-Claudin-8 antibody
Anti-CLDN8 antibody
Anti-UNQ779 antibody
Anti-PRO1573 antibody

Information sourced from Uniprot.org

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