Anti-CITED2 antibody [R01-2G8] (STJA0036220)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CITED2
General Information
| Short Description | Rabbit monoclonal anti-CITED2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-2G8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CITED2 |
| Gene ID | 10370 |
| Uniprot ID | CITE2_HUMAN |
| Immunogen | A synthesized peptide derived from human CITED2 |
Additional Info
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor.interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis.potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP).stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Cbp/P300-Interacting Transactivator 2Msg-Related Protein 1Mrg-1P35srj |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-9614657 |
| Cellular Localisation | NucleusColocalizes With Ep300 In Dot-Like Structures |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 2 antibodyAnti-Msg-Related Protein 1 antibodyAnti-Mrg-1 antibodyAnti-P35srj antibodyAnti-CITED2 antibodyAnti-MRG1 antibody |
Information sourced from Uniprot.org