| Tissue Specificity | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
| Post Translational Modifications | Tyrosine phosphorylated. Also phosphorylated by PKA. |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Cdc42-Interacting Protein 4Protein FelicSalt Tolerant ProteinHstpThyroid Receptor-Interacting Protein 10Tr-Interacting Protein 10Trip-10 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeGolgi ApparatusCell MembraneCell ProjectionPhagocytic CupTranslocates To The Plasma Membrane In Response To Insulin StimulationAnd This May Require Active RhoqLocalizes To Cortical Regions Coincident With F-ActinTo Lysosomes And To Sites Of Phagocytosis In MacrophagesAlso Localizes To The GolgiAnd This Requires Akap9Isoform 5: CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Cdc42-Interacting Protein 4 antibodyAnti-Protein Felic antibodyAnti-Salt Tolerant Protein antibodyAnti-Hstp antibodyAnti-Thyroid Receptor-Interacting Protein 10 antibodyAnti-Tr-Interacting Protein 10 antibodyAnti-Trip-10 antibodyAnti-TRIP10 antibodyAnti-CIP4 antibodyAnti-STOT antibodyAnti-STP antibody |
Information sourced from Uniprot.org
