• Western blot analysis of extracts of various cell lines, using CINP Rabbit polyclonal antibody antibody (STJ11104225) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CINP antibody (1-212) (STJ11104225)

SKU:
STJ11104225

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cyclin-Dependent Kinase 2-Interacting Protein (1-212) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CINP
Gene ID: 51550
Uniprot ID: CINP_HUMAN
Immunogen Region: 1-212
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human CINP (NP_116019.1).
Immunogen Sequence: MEAKTLGTVTPRKPVLSVSA RKIKDNAADWHNLILKWETL NDAGFTTANNIANLKISLLN KDKIELDSSSPASKENEEKV CLEYNEELEKLCEELQATLD GLTKIQVKMEKLSSTTKGIC ELENYHYGEESKRPPLFHTW PTTHFYEVSHKLLEMYRKEL LLKRTVAKELAHTGDPDLTL SYLSMWLHQPYVESDSRLHL ESMLLETGHRAL
Post Translational Modifications Phosphorylated by CDC7 but not by CDK2.
Function Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM.
Protein Name Cyclin-Dependent Kinase 2-Interacting Protein
Cdk2-Interacting Protein
Cellular Localisation Nucleus
Binds To Nuclear Under G1 Conditions
And Dissociates From Chromatin With The Start Of Dna Replication
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 2-Interacting Protein antibody
Anti-Cdk2-Interacting Protein antibody
Anti-CINP antibody

Information sourced from Uniprot.org

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