• STJ70969 (0. 03µg/ml) staining of rat spinal cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CILP antibody (Internal) (STJ70969)

SKU:
STJ70969-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CILP (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CILP
Gene ID: 8483
Uniprot ID: CILP1_HUMAN
Immunogen Region: Internal
Accession Number: NP_003604.2
Immunogen Sequence: NYRRTDHEDPRVK
Post Translational Modifications Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Protein Name Cartilage Intermediate Layer Protein 1
Cilp-1
Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2
Database Links Reactome: R-HSA-2404192
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Cartilage Intermediate Layer Protein 1 antibody
Anti-Cilp-1 antibody
Anti-Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 antibody
Anti-CILP antibody
Anti-UNQ602 antibody
Anti-PRO1188 antibody

Information sourced from Uniprot.org

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