Anti-CILP antibody (Internal) (STJ70969)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CILP (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 150kDa band observed in rat spinal cord lysates (calculated MW of 133kDa according to human NP_003604.2 and of 132kDa according to Rat NP_001101631.1). Recommended concentratio |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CILP |
| Gene ID | 8483 |
| Uniprot ID | CILP1_HUMAN |
| Accession Number | NP_003604.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | NYRRTDHEDPRVK |
Additional Info
| Post Translational Modifications | Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. |
| Function | Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
| Protein Name | Cartilage Intermediate Layer Protein 1Cilp-1Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 |
| Database Links | Reactome: R-HSA-2404192 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Cartilage Intermediate Layer Protein 1 antibodyAnti-Cilp-1 antibodyAnti-Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 antibodyAnti-CILP antibodyAnti-UNQ602 antibodyAnti-PRO1188 antibody |
Information sourced from Uniprot.org