| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIAO1 (1-339) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIAO1 |
| Gene ID: |
9391 |
| Uniprot ID: |
CIAO1_HUMAN |
| Immunogen Region: |
1-339 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CIAO1 (NP_004795.1). |
| Immunogen Sequence: |
MKDSLVLLGRVPAHPDSRCW FLAWNPAGTLLASCGGDRRI RIWGTEGDSWICKSVLSEGH QRTVRKVAWSPCGNYLASAS FDATTCIWKKNQDDFECVTT LEGHENEVKSVAWAPSGNLL ATCSRDKSVWVWEVDEEDEY ECVSVLNSHTQDVKHVVWHP SQELLASASYDDTVKLYREE EDDWVCCATLEGHESTVWSL AFDPSGQRLASCSDDRTVRI WRQYLPGNEQGVACSGSDP |
| Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
| Protein Name | Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1Wd Repeat-Containing Protein 39 |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1 antibodyAnti-Wd Repeat-Containing Protein 39 antibodyAnti-CIAO1 antibodyAnti-CIA1 antibodyAnti-WDR39 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
