| Tissue Specificity | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-10Nicotinic Acetylcholine Receptor Subunit Alpha-10Nachr Alpha-10 |
| Database Links | Reactome: R-HSA-9667769 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-10 antibodyAnti-Nicotinic Acetylcholine Receptor Subunit Alpha-10 antibodyAnti-Nachr Alpha-10 antibodyAnti-CHRNA10 antibodyAnti-NACHRA10 antibody |
Information sourced from Uniprot.org
