| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CHN2 (150-180) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.68-0.71 µg/µl |
| Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | CHN2 |
| Gene ID: | 1124 |
| Uniprot ID: | CHIO_HUMAN |
| Immunogen Region: | 150-180 |
| Immunogen: | Synthetic peptide taken within amino acid region 150-180 on beta 2-chimaerin protein. |
| Tissue Specificity | Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas. |
| Function | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| Protein Name | Beta-Chimaerin Beta-Chimerin Rho Gtpase-Activating Protein 3 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | Membrane Peripheral Membrane Protein |
| Alternative Antibody Names | Anti-Beta-Chimaerin antibody Anti-Beta-Chimerin antibody Anti-Rho Gtpase-Activating Protein 3 antibody Anti-CHN2 antibody Anti-ARHGAP3 antibody Anti-BCH antibody |
Information sourced from Uniprot.org