| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHMP2B (1-213) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHMP2B |
| Gene ID: |
25978 |
| Uniprot ID: |
CHM2B_HUMAN |
| Immunogen Region: |
1-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human CHMP2B (NP_054762.2). |
| Immunogen Sequence: |
MASLFKKKTVDDVIKEQNRE LRGTQRAIIRDRAALEKQEK QLELEIKKMAKIGNKEACKV LAKQLVHLRKQKTRTFAVSS KVTSMSTQTKVMNSQMKMAG AMSTTAKTMQAVNKKMDPQK TLQTMQNFQKENMKMEMTEE MINDTLDDIFDGSDDEEESQ DIVNQVLDEIGIEISGKMAK APSAARSLPSASTSKATISD EEIERQLKALGVD |
| Tissue Specificity | Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Protein Name | Charged Multivesicular Body Protein 2bChmp2.5Chromatin-Modifying Protein 2bChmp2bVacuolar Protein Sorting-Associated Protein 2-2Vps2-2Hvps2-2 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-1632852Reactome: R-HSA-5620971Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710Reactome: R-HSA-9668328Reactome: R-HSA-9679504Reactome: R-HSA-9694676 |
| Cellular Localisation | CytoplasmCytosolLate Endosome MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Charged Multivesicular Body Protein 2b antibodyAnti-Chmp2.5 antibodyAnti-Chromatin-Modifying Protein 2b antibodyAnti-Chmp2b antibodyAnti-Vacuolar Protein Sorting-Associated Protein 2-2 antibodyAnti-Vps2-2 antibodyAnti-Hvps2-2 antibodyAnti-CHMP2B antibodyAnti-CGI-84 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
