| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CHML |
| Gene ID: | 1122 |
| Uniprot ID: | RAE2_HUMAN |
| Immunogen Region: | 1-100 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHML (NP_001812.2). |
| Immunogen Sequence: | MADNLPTEFDVVIIGTGLPE SILAAACSRSGQRVLHIDSR SYYGGNWASFSFSGLLSWLK EYQQNNDIGEESTVVWQDLI HETEEAITLRKKDETIQHTE |
| Function | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. |
| Protein Name | Rab Proteins Geranylgeranyltransferase Component A 2Choroideremia-Like ProteinRab Escort Protein 2Rep-2 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Rab Proteins Geranylgeranyltransferase Component A 2 antibodyAnti-Choroideremia-Like Protein antibodyAnti-Rab Escort Protein 2 antibodyAnti-Rep-2 antibodyAnti-CHML antibodyAnti-REP2 antibody |
Information sourced from Uniprot.org