| Short Description : | Rabbit monoclonal Rab Proteins Geranylgeranyltransferase Component A 1 (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5752RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHM |
| Gene ID: | 1121 |
| Uniprot ID: | RAE1_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MADTLPSEFDVIVIGTGLPE SIIAAACSRSGRRVLHVDSR SYYGGNWASFSFSGLLSWLK EYQENSDIVSDSPVWQDQIL ENEEAIALSRKDKTIQHVEV |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386). |
| Function | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. |
| Protein Name | Rab Proteins Geranylgeranyltransferase Component A 1Choroideremia ProteinRab Escort Protein 1Rep-1Tcd Protein |
| Database Links | Reactome: R-HSA-6803205Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibodyAnti-Choroideremia Protein antibodyAnti-Rab Escort Protein 1 antibodyAnti-Rep-1 antibodyAnti-Tcd Protein antibodyAnti-CHM antibodyAnti-REP1 antibodyAnti-TCD antibody |
Information sourced from Uniprot.org
