| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Rab Proteins Geranylgeranyltransferase Component A 1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5752RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHM |
| Gene ID: |
1121 |
| Uniprot ID: |
RAE1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386). |
| Immunogen Sequence: |
MADTLPSEFDVIVIGTGLPE SIIAAACSRSGRRVLHVDSR SYYGGNWASFSFSGLLSWLK EYQENSDIVSDSPVWQDQIL ENEEAIALSRKDKTIQHVEV |
| Function | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. |
| Protein Name | Rab Proteins Geranylgeranyltransferase Component A 1Choroideremia ProteinRab Escort Protein 1Rep-1Tcd Protein |
| Database Links | Reactome: R-HSA-6803205Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibodyAnti-Choroideremia Protein antibodyAnti-Rab Escort Protein 1 antibodyAnti-Rep-1 antibodyAnti-Tcd Protein antibodyAnti-CHM antibodyAnti-REP1 antibodyAnti-TCD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
